IBM and AMD have announced a new collaboration with Zyphra, an open-source AI research company based in San Francisco. The agreement will see IBM provide Zyphra with access to a large cluster of AMD Instinct MI300X GPUs on IBM Cloud. This infrastructure is intended for training advanced multimodal foundation models, which will support Zyphra’s development of AI systems.
The partnership marks the first large-scale deployment of AMD’s latest GPU technology, along with networking and data processing units, on IBM Cloud for a client focused on frontier model development. Initial access was granted to Zyphra in early September 2025, with further expansion planned for 2026.
Zyphra recently completed a Series A financing round that valued the company at $1 billion. The funding supports its goal to build an open-source superintelligence lab dedicated to innovation in neural network architectures and continual learning.
Krithik Puthalath, CEO and Chairman of Zyphra, commented: “This collaboration marks the first time AMD’s full-stack training platform—spanning compute through networking—has been successfully integrated and scaled on IBM Cloud, and Zyphra is honored to lead the way in developing frontier models with AMD silicon on IBM Cloud. We’re excited to partner with IBM and AMD to power the next era of open-source, enterprise superintelligence.”
The training cluster provided by IBM and powered by AMD hardware will be used by Zyphra to develop models that can handle language, vision, and audio data simultaneously. These efforts aim to support Maia, a general-purpose AI agent designed to help knowledge workers across various enterprises.
Alan Peacock, GM of IBM Cloud, stated: “Scaling AI workloads faster and more efficiently is a key differentiator in achieving ROI for established enterprises and emerging companies alike. We are delighted to support Zyphra’s strategic roadmap as we collaborate with AMD to deliver scalable, economical AI infrastructure that can accelerate Zyphra’s model training.”
Philip Guido, EVP and Chief Commercial Officer at AMD said: “The IBM and AMD collaboration delivers innovation at the speed and scale clients demand, representing a new standard in AI infrastructure. By combining IBM enterprise cloud expertise with AMD leadership in high-performance computing and AI acceleration, we are supporting Zyphra’s pioneering work in multimodal and inference-efficient AI, enabling organizations everywhere to build smarter businesses and unlock AI solutions that drive real-world outcomes.”
IBM Cloud has been recognized for its security features as well as reliability and scalability for demanding workloads such as generative AI models. Last year, both companies began offering AMD Instinct MI300X accelerators as a service through the cloud platform.
Both companies also plan future work together on quantum-centric supercomputing architectures that combine quantum computers from IBM with high-performance computing capabilities from AMD.
More information about the partnership between IBM Cloud and AMD can be found at https://www.ibm.com/products/gpu-ai-accelerator/amd
